Information about medications, their effects, treatment.

Lopressor
Active ingredient: Metoprolol

Metoprolol (Lopressor): 12.5 mg; 25 mg.

Cardioselective beta-1 blocker. Does not have a membrane-stabilizing action and does not have an internal AGR. Has antihypertensive, anti-angiogenic and antiarrhythmic action. It is used for IHD, angina pectoris, unstable angina, myocardial infarction, arterial hypertension, hypertensive crisis, tachycardia, thyrotoxicosis.

Lopressor is used for treating high blood pressure, alone or with other medicines; long-term treatment of chest pain; and reducing the risk of death because of heart problems in patients who have had a heart attack.

Lopressor as known as: Dutoprol, Lopressor hct, Toprol-xl

INDICATIONS

Lopressor is used for treating high blood pressure, alone or with other medicines; long-term treatment of chest pain; and reducing the risk of death because of heart problems in patients who have had a heart attack. Lopressor is a beta-adrenergic blocking agent (beta-blocker). It works by reducing the amount of work the heart has to do (reduces chest pain) and the amount of blood the heart pumps out (lowers high blood pressure). It is also used to stabilize the heart rhythm in conditions in which the heart is beating too fast or at an irregular rhythm.

INSTRUCTIONS

Use Lopressor as directed by your doctor.

• Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
• Take Lopressor at the same time every day.
• Lopressor should be taken with food or just after a meal.
• Do not skip doses or stop taking Lopressor without first talking to your doctor. Stopping suddenly may make your condition worse.
• Your blood pressure will need to be checked often. Visit your doctor regularly.
• If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
• If you miss a dose of Lopressor (Metoprolol), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lopressor.

STORAGE

Store Lopressor at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lopressor out of the reach of children and away from pets.

Cardiac ischemia

Coronary heart disease is a serious disease in which the coronary arteries are damaged, which in turn affects the myocardium. This happens due to the fact that the myocardium’s need for oxygen is greater than what is actually supplied from the blood. Coronary artery disease can have a chronic course, when the patient is bothered by periodic attacks of angina, or an acute course – myocardial infarction.

How often do people get coronary heart disease?

Coronary artery disease is a common cardiovascular disease and one of the leading causes of mortality. Moreover, men are more susceptible to this disease than women.

What types of coronary disease exist?

Depending on the clinical manifestations of the disease, the following types of coronary heart disease are distinguished:

1. Silent myocardial ischemia.
2. Angina.
3. Myocardial infarction.
4. Cardiosclerosis that developed after a heart attack.
5. Primary cardiac arrest.
6. Heart rhythm disturbance.

When making a diagnosis, the doctor must indicate the form of the disease.

Who is susceptible to developing coronary artery disease?

The main factor in the development of coronary artery disease is atherosclerosis, a chronic disease in which protein and fat metabolism is disrupted, resulting in the deposition of cholesterol in the lumen of blood vessels. But there are also a lot of other factors.

1. Biological:
   • age-related changes;
   • gender (the disease is more likely to develop in men);
   • predisposition to diabetes, obesity and hypertension.
2. Anatomical and physiological (already existing diseases):
   • lipid metabolism disorders;
   • hypertension;
   • diabetes;
   • excess weight.
3. Features of human behavior and habits:
   • irregular eating, overeating and an abundance of fatty foods in the diet;
   • bad habits (drinking alcohol, smoking, drug addiction);
   • physical inactivity.

Also, the development of coronary disease is affected by a mutation in one of the body’s genes (CDH13).

What is ischemic disease?

The basis for the development of coronary disease is insufficient blood supply to the myocardium, which can occur due to the following factors:

1. Disorders that develop outside the blood vessels.
   o pathological increase in heart rate (more than 90 beats per minute);
   o high blood pressure;
   o enlargement of the myocardium.
2. Vascular disorders.
   o vascular atherosclerosis;
   o spasm of coronary vessels;
   o thrombosis.

Atherosclerosis of the heart vessels is the most common cause that leads to impaired blood supply to the heart. This disease develops gradually and is characterized by elevated cholesterol levels, with the formation of so-called plaques. The subsequent accumulation of lipids in the cholesterol plaque leads to rupture of its fibrous cover, followed by the deposition of glued platelets (aggregates) and the deposition of fibrin protein in this place. Next, the thrombus is covered with cells that make up the walls of blood vessels (endothelium) and a narrowing (stenosis) is formed. This condition affects the blood supply, and depending on where the narrowing occurs, ischemia can be either mild or very severe.

To determine coronary artery disease, a so-called stress test is performed, which helps the doctor determine the cause of chest pain. The patient exercises on an exercise bike, and at this time his blood pressure is monitored, and electrocardiogram readings are also noted. If during physical activity there is a lack of oxygen in the myocardium, this confirms that the patient has coronary artery disease. This method also helps determine the severity of the disease, and whether the patient needs only drug treatment, or additional studies (for example, coronary angiography) are needed.What tests are needed to detect coronary artery disease?

How is coronary disease treated?

Drug therapy is aimed at improving the prognosis of the disease. The patient is prescribed medications to thin the blood and lower cholesterol (sterol) levels. Adrenergic blockers, such as Metoprolol, are also prescribed to relieve symptoms. This drug is also good for patients who have had a previous heart attack and have symptoms of heart failure.

How often should you see a doctor?

Regardless of the severity of the disease, it is very important to regularly visit a specialist (cardiologist). During the visit, the effectiveness of treatment is assessed. People have individual health conditions, so sometimes it is necessary to change the dosage of medications, as well as prescribe additional procedures if the patient’s condition worsens.

How does the beta blocker Metoprolol work?

Metoprolol is a selective beta-blocker that acts primarily on myocardial beta-one receptors. Unlike non-selective drugs, Metoprolol has virtually no effect on the smooth muscles of the bronchi and peripheral arteries, insulin production and fat metabolism.

Lopressor (Metoprolol) has a cumulative effect and stabilization of blood pressure is observed after two weeks of use. Patients note a decrease in the intensity and frequency of attacks, as well as an increase in endurance during physical activity. The heart rate returns to normal.

How to use Metoprolol/Lopressor?

The dosage of the drug is prescribed individually. For high blood pressure, 50 to 100 mg per day is prescribed. In acute myocardial infarction, 50 mg is prescribed twice a day, with a possible increase in dosage to 100 mg twice a day. The duration of treatment is at least 3 months under medical supervision. If there is a need to discontinue the drug, this is done gradually over 10 days with a gradual reduction in dosage.

Metoprolol is not recommended for use in the following conditions:Who is contraindicated for taking Metoprolol?

• severe liver or kidney failure;
• sick sinus syndrome;
• bradycardia, in which the heart rate is below 55 beats per minute;
• uncompensated heart failure;
• pregnancy and lactation;
• 2-3 degree AV block;
• systolic pressure below 90 mmHg. Art.;
• individual sensitivity to Metoprolol.

Where can I buy Metoprolol/Lopressor at a good price?

Metoprolol can be bought in pharmacies. And, as a rule, a doctor’s prescription is required to purchase it. In addition, the original drug has a high cost. In our online pharmacy you can order generic Metoprolol – a cheap and high-quality analogue. It is no different from the original drug in action, since it is developed on the basis of an identical active ingredient. And its low price is explained by the fact that there is no need to conduct research on the drug, because it has already been studied. Thus, generic Metoprolol is a good inexpensive alternative to the original drug. And it can be ordered online without a doctor’s prescription. It is important to understand that such a potent medicine can only be prescribed by a doctor and self-medication is very dangerous.

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